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SUMMARY:BIPS Institute Seminar: "Beyond DNA Damage: Diverse Cellular Responses to Ionizing Radiation"
DESCRIPTION:This webinar is hosted by the Leibniz Institute for Prevention Research and Epidemiology (BIPS). \n\n\n\n\n\n\n\nAbstract \nIonizing radiation exerts its biological effects primarily through the induction of DNA damage\, particularly DNA double-strand breaks (DSBs). Activation of the DNA damage response (DDR) regulates cell-cycle arrest\, DNA repair\, apoptosis\, and cellular senescence\, thereby contributing to tumor control. However\, recent studies have shown that radiation-induced cellular responses extend beyond DNA damage. Reactive oxygen species (ROS)\, lipid peroxidation\, metabolic reprogramming\, and extracellular vesicle-mediated intercellular communication also influence cell fate and therapeutic outcomes. \n  \nThese biological responses are strongly influenced by radiation quality. Low-linear energy transfer (LET) radiation\, such as X-rays and γ-rays\, mainly induces dispersed DNA damage\, whereas high-LET radiation\, including carbon-ion beams\, generates clustered and complex DNA damage that is considerably more difficult to repair. Furthermore\, ultra-high dose-rate (FLASH) irradiation has emerged as a promising approach that maintains tumor control while reducing normal tissue toxicity. Radiation quality and dose rate therefore influence not only DNA damage but also oxidative stress\, redox homeostasis\, and intracellular signaling. \n  \nRecent attention has focused on non-canonical forms of radiation-induced cell death. Ferroptosis\, an iron-dependent regulated cell death driven by lipid peroxidation\, has emerged as a determinant of radiosensitivity and a potential therapeutic target for apoptosis-resistant tumors. Ionizing radiation can also modulate anoikis\, cell adhesion signaling\, cytoskeletal organization\, and epithelial–mesenchymal plasticity\, thereby influencing tumor invasion and metastatic potential. \n  \nThis lecture will provide an overview of the diverse cellular responses to ionizing radiation\, focusing on DNA damage responses\, the biological effects of radiation quality\, and emerging mechanisms of radiation-induced cell death and metastasis suppression.\n\n\n\n\n\n\n\n  \n\n\n\n\n\n\n\nAbout the speaker \nDr. Kazumasa Minami is Associate Professor in the Division of Health Sciences\, Graduate School of Medicine\, The University of Osaka (UOsaka). He has held academic and research positions at UOsaka since 2013\, including appointments in radiation oncology\, health sciences\, and the Cancer Professional Training Program. From 2014 to 2016\, Dr. Minami was a Postdoctoral Research Fellow at the Indiana University Purdue University Indianapolis (IUPUI) School of Medicine in the United States. After returning to Japan\, he served in several faculty positions at UOsaka\, including Specially Appointed Assistant Professor and Assistant Professor in Radiation Oncology and Health Sciences. Since 2025\, Dr. Minami has also been affiliated with the National Institute of Science and Technology Policy. His work is in the fields of radiation oncology and health sciences.
URL:https://bvsabr.be/event/bips-institute-seminar-beyond-dna-damage-diverse-cellular-responses-to-ionizing-radiation/
LOCATION:Online
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